IL-17F rs763780T>C polymorphism contributes to the development of coronary artery disease in a Chinese population

We conducted a case-control study to investigate the role of IL-17A (rs2275913G>A and rs3748067C>T) and IL-17F (rs763780 T>C) gene polymorphisms in the susceptibility to CAD in a Chinese population. Between July 2013 and December 2014, a total of 184 patients with CAD and 184 control subjects were consecutively selected from the Hebei General Hospital. The IL-17A rs2275913G>A and rs3748067C>T and IL-17F rs763780T>C polymorphisms were genotyped using PCR-RFLP. By chi-square test, a significant different was found in the genotype distributions of IL-17A rs2275913G>A between CAD patients and control subjects (χ2=0.66, P=0.72). By unconditional multiple logistic regression analysis, we found that the CC and TC+CC genotypes of IL-17F rs763780T>C was associated with increased risk of CAD when compared with the TT genotype, and the adjusted OR (95% CI) was 3.55 (1.20-12.66) and 1.71 (1.03-2.97), respectively. However, no significant association was found between IL-17A rs2275913G>A and rs3748067C>T and development of CAD. In our study, we suggest that IL-17F rs763780T>C polymorphism could influence the development of CAD in a Chinese population.